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п»їChordoma Treatment,Chordoma Treatment in India at Affordable Cost, Mumbai Delhi Chordoma

Chordoma

Overview

Chordomas are locally invasive tumors that arise from the remnant of the primitive notochord. They occur most commonly in the skull base (clivus) and lower spine; approximately 40% of chordomas and chondrosarcomas arise in the clivus. Chordomas are often considered a benign tumor because of their slow growth. However, some chordomas behave aggressively and have more malignant characteristics with extensive invasiveness including a small subset of patients (~10%) that develop metastases to distant sites beyond their site of origin.

Types of Chordoma

There are three histological subtypes of chordoma: conventional (sometimes called classic), chondroid, and dedifferentiated. Chondroid chordomas tend to be less aggressive than conventional chordomas, while dedifferentiated chordomas are more aggressive, faster growing and more likely to metastasize.

Chordomas are often confused with or misdiagnosed as chondrosarcomas, and vice versa.[3] Both types of tumor can occur in the same locations and often look similar under a microscope. Generally, chondrosarcomas tend to be more responsive to radiation and have a better prognosis.[3] Therefore before proceeding with treatment, it is important to get multiple opinions on the pathological diagnosis from experienced pathologists who routinely see both types of tumors.

SYMPTOMS

Most patients with a clival chordoma develop headaches and double vision. Less common symptoms include visual loss, hearing loss, difficulty swallowing, facial numbness, in-coordination and motor weakness.

DIAGNOSIS

These skull base tumors are best diagnosed by MRI and CT scans which will clearly show the extent of tumor and bony destruction. Focused MRIs of the pituitary region, sinuses, temporal bones or internal auditory canals may be indicated to obtain better anatomical detail of a chordoma. Other tests may also be needed prior to surgery such as angiography (typically now performed as a CT angiogram or an MR angiogram), visual field tests, an audiogram or hormonal tests.

Several different scans are done to locate the tumor. Two of the most common are the computed tomography (CT or CAT) scan and magnetic resonance imaging (MRI). A CT scan uses x-ray images taken from many angles and computer reconstruction to show parts of the body in cross section. This helps to locate and estimate the size the tumor, and provides information on whether it can be surgically removed. MRI uses magnets and radio waves to create more detailed cross-sectional scans than computed tomography. There are many variations on these two scans that use dyes or radioactive materials to provide information about blood flow around the tumor and help determine whether the tumor can be surgically removed.

Treatment

Surgery

Currently, surgery is the first-line treatment for chordomas. Complete resection (removing the entire tumor) during the first surgery provides the best chances for local control and long-term survival.To achieve a complete resection, aggressive surgery is often required and can lead to significant complications or side-effects.

The goal of surgery should be to remove as much of the tumor as possible without causing unacceptable harm. Because outcome and prognosis are largely dependent on the success of the initial surgery, before having any operation it is very important to get multiple opinions from surgical teams who have experience treating chordomas on a regular basis. Some medical centers have multidisciplinary teams of experts who review cases and can help create a coordinated treatment plan for patients with chordomas.

Radiotherapy

In many cases, radiation therapy following surgery is recommended and can improve chances of local control and survival. Because chordomas do not grow rapidly, high doses of radiation are required to kill the tumor cells. Chordomas that are close to critical structures (arteries, brain, brainstem, cranial nerves, dura, spinal nerves), often limit the dose of radiation that can be safely delivered to the tumor. In most cases, proton beam radiation can maximize the dose of radiation to the tumor, while sparing adjacent critical structures. Intensity modulated radiation therapy (IMRT), stereotactic radiosurgery and carbon-ion radiotherapy are also sometimes used to treat chordoma.

Chemotherapy

Chordomas are generally resistant to standard cytotoxic chemotherapy agents, and there are no drugs approved to treat chordoma. Dedifferentiated chordomas are sometimes treated with chemotherapy to kill rapidly multiplying cells. Recently, GleevecВ® (imatinib) has been shown to have antitumor effects in some patients with advanced chordomas.Additionally, off-label use of other targeted therapies such as ERBITUX (cetixumab), Iressa (gefinitinib), TarcevaВ® (erlotinib) have been reported.

Chordomas are often confused with or misdiagnosed as chondrosarcomas, and vice versa.[3] Both types of tumor can occur in the same locations and often look similar under a microscope. Generally, chondrosarcomas tend to be more responsive to radiation and have a better prognosis.[3] Therefore before proceeding with treatment, it is important to get multiple opinions on the pathological diagnosis from experienced pathologists who routinely see both types of tumors.

SYMPTOMS

Most patients with a clival chordoma develop headaches and double vision. Less common symptoms include visual loss, hearing loss, difficulty swallowing, facial numbness, in-coordination and motor weakness.

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п»їCombine Local SEO Consulting Service With Social Media Marketing To Achieve Top Search Engine Placement

Local SEO consulting service companies are dedicated companies that offer SEO consulting services to local small businesses in order to help them achieve top search engine placement in Google and other major search engines. Local Search Engine Optimization is a highly effective way of targeting your local customers, especially if you are the type of business that offers services within a specific geographical area like a city or a state. Local SEO will significantly improve search engine ranking and increase targeted traffic from your local potential clients. By improving search engine rankings, a website will be found by more targeted visitors. Ultimately, sales, revenues and return on investment will increase.
In today's challenging markets small businesses on the web are faced with the challenge of competing with other companies in the same niche. It means that gaining exposure and bringing visitors to the site becomes difficult as well.
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Combining social media marketing and other methods of internet advertisement with local SEO marketing will definitely give any business an edge in competing against other similar businesses. Internet marketing is a multifaceted game and social media is part of the whole game. Your small business should take advantage of social media tools such as social networking and social bookmarking websites in order to have the most effective promotional campaign.
Many SEO firms provide affordable search engine optimization consulting and training services to help small businesses to plan different search engine optimization strategies to improve their ranking. It is highly recommended that small businesses work with a professional SEO expert who knows the ins and outs of internet marketing in order to help businesses survive and grow on the internet.
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Online Payday Cash Advance - Whу Dо Yоu Nееd It?

Thе cyclical passages оf mоѕt salaried people iѕ thеrе аrе ѕо mаnу timеѕ wе gоt money in оnе hаnd оn salary day thеn givе it аll аwау tо pay bills аnd expenses in оthеr hand. It ѕееmѕ thеrе iѕ nеvеr adequate cash left оvеr tо cover уоu аnd уоur family's basic expenses еvеrу month еvеn thоugh уоu аlrеаdу work rеаllу hard. Thеn ѕоmе unanticipated expenses happen; thе car nееd tо bе repaired, medical bills nееd tо bе paid, etc. thоѕе аrе unexpected fоr everybody. Whеn уоur financial situation turns оut оf thе blue, a short term solution likе thе online payday cash advance iѕ badly needed.

Yоu nееd tо seek оthеr sources inѕtеаd оf уоur salary tо fill thiѕ financial gap ѕuсh аѕ frоm уоur credit cards. It wоn't lead tо mоrе problems if уоur credit condition iѕ healthy аnd аt ѕоmе point уоu саn cover thе gap temporarily. Uѕing credit cards fоr thiѕ purpose ѕhоuld bе with careful consideration tо hаvе уоur debt kерt managed properly. Sоmе people due tо a reckless usage in thеir credit card еvеn аrе trapped in debt cycles thаt еnd uр with a higher interest burden day bу day.

Thе оthеr option mау bе borrowing ѕоmе cash frоm уоur employer, friends, оr relatives whiсh аrе bеѕt available. At ѕоmе timе уоu mау bе аblе tо trу thiѕ option but thеrе will bе a limitation bесаuѕе nоt еvеrу timе уоu саn borrow thе money frоm them. Thеrе аrе lots оf hassles eventually. Sо thiѕ iѕ trulу аn inevitable condition аnd bеfоrе уоu саn switch уоur financial in a good cash flow standing, аn online payday cash advance mау bе уоur solution.

Online payday cash advance iѕ bridging small cash, typically undеr $1500 loaned bу banks оr small lending institutions with short term loan period (usually within 2 weeks) thаt саn bе provided online. Thе process iѕ secured bу a borrower's postdated check оr аn authorized withdrawal permission оf borrower's bank account аѕ thе collateral hold bу lender until thе timе оf payday. In average thеrе iѕ a fee аbоut $15 tо $30 реr $100 loaned with thе annual percentage rates iѕ starting frоm аbоut 300%. If уоu fail tо repay оf thе loan whеn thе timе соmе due уоu ѕhоuld extent оr roll оvеr fоr nеxt payday cash loan with extra fees аnd interest fоr thаt period оf extension. Thоѕе аrе thе wау whеrе a payday loan lender make money.

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п»їDoes The Concept Of Selling Adult Play Toys Over E Commerce Platform Appeal To An Indian Audience?

Sale of adult play toys is something which is otherwise seen as a taboo, and even an idea which does not find widespread acceptance amongst people. Nevertheless, one might over time find out that most people just see these as sexual wellness products, and something which they would not associate with any of the notions of vulgarity.
If someone has it in mind to set up a company which is entirely dedicated to sale of adult playtoys, they would have to give a great degree of consideration to the sensibilities of the local audience.
In the same way, a challenge which such an idea faces is finding the right kind of niche audience who would be interested in purchasing adult play toys.
Nevertheless, it is a very commonly believed notion that when people from India are on a lookout for adult play toys, they normally make a purchase from abroad. Or they may even have to go for substandard goods from those available at e commerce stores.
There is invariably a compromise on satisfaction levels, because finding a large variety of adult play toys at a single destination could be tough. And in the same way, if one does want to go for adult play toys, it might occasionally be difficult to find the best quality of products.
Mr. Chavan had these ideas in mind when he was planning to set up twinkleknights.com. And correspondingly, it took him atleast an year of research to figure out the feasibility of such a website for Indian markets.
Over the phase, Mr. Chavan came to realize that the number of people who would want to go for such a service is high, pretty much higher than one would otherwise presume.
People from India are opening up in their attitude towards adult play toys and a majority of the audience cross section is pretty much comfortable regarding the sale and use of adult play toys.
As Mr. Chavan himself said, that ‘If a couple intends to find joy in the bedroom, there is no reason why they should hold back. It’s really a no bars attached idea of fun which two mature people may want to indulge into.’
‘And if a website which sells adult play toys makes it easier for them to achieve the same, there is no reason why one must say no to such an idea. Because ultimately, one’s sexual wellness reflects in everything that one does and in one’s everyday activities as well.’ Mr. Chavan went on to add.
WHAT MAKES TWINKLEKNIGHTS DIFFERENT FROM A RANDOM WEBSITE WHICH MAY SELL ADULT PLAY TOYS?
TwinkleKnights banks on a unique concept for selling adult play toys. A majority of products sold on the website are high tech goods, something which other websites may not be doing. And moreover, Team Twinkleknights works dedicated towards assuring that each of the products which the website sells is.
- High quality
- Complies with the safety standards, i.e. the goods are, in most cases made using a high quality liquid silicone material, which ensures quality and durability as well. Making sure that each of the goods is of a high quality is of great importance, Mr. Chavan explained, for the simple reason that they do not cause injury to a user or have any allergic reactions.
‘The hi tech sensuality playtoys that are sold on the website makes twinkleknights a unique concept, something that is entirely new to the Indian markets’, Mr. Chavan expressed. ‘It is something that is sure to further capture the amusement and fantasy of Indian audience, because while a section of the audience is middle aged, another section of the audience is young and willing to spend’ he went on to say.
‘Another notable point is that’, Mr. Chavan told our team of correspondents, ‘it is really surprising to note that nearly 70% of the consumers are women. Women are more comfortable in their attitude towards adult play toys than they have ever been, and find it perfectly alright to purchase one for personal use or for use with their partner.’
WHAT IS HI TECH SENSUALITY?
TwinkleKnights sells hi tech sensuality goods, and the hi tech sensuality refers to sale of goods which make use of technology to promote a much higher degree of sexual wellness amongst users, or even work towards resolving medical issues.
Let’s consider some examples which would explain how well twinkleknights has achieved use technology for achieving higher sexual wellness for the people.
1. ProFitMe
Pro Fit Me is a prostate massager for men. Prostate is an organ which is responsible for production of semen in men, and it is stimulated via the anterior walls of the rectum.
A prostate massage ensures a much improved overall health for men. This effectively works towards mitigating
o risk of prostate cancer
o genital pain
o symptoms of erectile dysfunction
o frequent nighttime urination
o and increases seminal fluid and circulation

2. V-tight Kegel Balls
Kegel balls are something designed to make ladies’ pelvic muscles stronger over time. In essence, it is nothing but a set of two balls attached to each other by a string.
So all one needs to do is push both the balls up the vagina, one by one and let them stay. Over time, as one does some practice with kegel balls, pelvic floor muscles are stronger, and this lets a sexual intercourse be more pleasurable, for a lady and her partner alike. This is required because after childbirth, the pelvic floor muscles might lose some of their elasticity, so the kegel balls make all the difference.
We find some websites over the internet which sells kegel balls, but twinkleknights does the stuff with a difference. Team Twinkle Knights has made use of technology to make sure that the Kegel balls work better and even quicker to let one achieve her goals for toned up pelvic muscles.
V-tight kegel balls are
o Programmed to interact with your smartphone through an app and send information by the use of Bluetooth.
o Designed to work in multiple levels of exercise. So as you get to one of the stages, the wireless signals are automatically sent to the v-tight kegel balls. So they can start with the next level of operation.
And that’s how technology is integrated with something that might otherwise be seen just as an adult play toy.

The last example that we consider exemplifies in a very typical way how technology is used to let people find even more joy in some everyday activities, and multiplies the happiness manifolds.
3. Pleasure V
Pleasure-V combines innovation of technology and age old KamaSutra techniques to deliver you an experience unmatched by any other source. It is a combination of cutting edge virtual reality on your own smartphone, which is fit into the virtual reality helmet.
Pleasure V combines Interactive VR Wristband + VR Helmet in a single package
o Interactive VR wristband is a motion sensing wristband which you wear when you masturbate.
o With the Virtual Reality helmet, you see adult images which correspondingly adjust intensity of sequence with the signals received from the VR wristband.

Over the years, twinkleknights.com has come across as a brand which makes dedicated efforts to ensure consumer satisfaction; this invariably includes addressing the queries of consumers and ensuring timely delivery of goods. And luckily, as Mr. Chavan expresses, the benefits too have started coming. The brand now ships goods to all places in the world.
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п»їHow To Avoid Affiliate Scams Online

The internet presents plenty of opportunities for those seeking to make money online. One such opportunity is affiliate marketing. However, no matter what venture you are investing your time and money in, there are always scammers plotting to separate you from your hard earned money; and affiliate marketing is no different. Thus, if you are planning on entering the affiliate marketing business, then you need to take caution to detect and avoid affiliate scams.

"If it is too good to be true, then chances are it is." This adage is not only applicable to life; it is also relevant in the world of affiliate marketing. While figuring out how to avoid affiliate marketing scams, it is important to acknowledge that there is no such thing as free lunch in this industry. Every successful affiliate work for every dime they make. Very few affiliate marketers have actually landed that pot of gold at the end of the rainbow. Most affiliate scammers target the novice and those who want to make quick bucks online. It is estimated that 1 in 20 online affiliate programs are scams. As such it is important that you do adequate research before signing up for any program.

Common affiliate scams.

Copying of legit affiliate site's content In this case, the scam involves copying or cloning a legitimate site in order to appear to be both popular and well respected. Copying often involves duplication of both the content and the styling as well. This confuses potential customers into making purchases from the wrong site, thus denying the genuine merchant of the sale.

Spamming. Spam email may be the number one nuisance of the internet age. While most people will delete such mails without a second thought, there are a few who respond to them and make a purchase, hence the continuation. By purchasing from spammers, not only are buyers perpetuating the problem, they are also depriving ethical merchants of sales and income. In addition, spams can also damage the reputation of genuine merchants by association.

Domain squatting. This is another common affiliate scam. With domain squatting, the scammer targets a successful merchant site and then registers several domain names that are close variations of the same, usually through missed spellings. When a potential client conducts a search term, they are greeted with what appears to be the genuine site and may end up making purchase from there, again denying the ethical merchant of sales.

Parasites and diversion of traffic. Parasites target and divert traffic from a legitimate affiliate marketing site, thus bypassing the intended vendor. Simply put, this is achieved through creation of dummy affiliate links on sites where affiliates sign up for products or services to promote. Thus, when a potential buyer clicks on the dummy affiliate link, they are directed to a faux site from where they do their purchase thus denying the legit merchant of revenue.

Fake referrals and links. This is probably one of the most common affiliate scams. This can take the form of repeat clicks on a link that pays on a CPC (cost per click) basis. Such fraudulent action drains cash from merchants without yielding any sale whatsoever. This is perpetuated by unethical affiliates looking to inflate their income or competitors looking to harm the affiliate.

Credit card and identity theft. You can never talk about how to avoid affiliate scams online without mentioning the age old problem of credit card and identity theft. Merchants generally make money through commissions earned from sales. In an event that the transaction was done using a stolen credit card, resulting in the cancelation of a sale, then the merchant may end up losing money in the form of chargebacks as well as bank fees.

Preventing affiliate scams.

Preventing affiliate scams online is far from easy due to the various forms it takes as well as the individuals behind it who tend to stay undetected for long periods of time. Here are a few precautions that you can take when figuring out how to avoid affiliate scams online.

Avoid unscrupulous affiliate marketing sponsors. Most affiliate program sponsors fully understand that a happy and successful affiliate is beneficial for their business. Unfortunately, some by the night sponsors come into the industry with ulterior motives. Thus, before signing up for any affiliate marketing program, it is important that you carefully screen the program sponsors' background in terms of the record of accomplishment, regular payouts, other affiliates' experience and grievance redressal among other parameters.

Be wary of unrealistically high payouts. Some affiliate sponsors set very high minimum payout threshold. This means that you have to earn a significant amount of money to receive a payout. Instead, opt for affiliate programs with reasonable payout limits. A significantly high payout limit should raise suspicion in your mind and you should be carefully thinking through before signing up to such programs.

Look at the programs tracking system. It is important that the affiliate program has a credible and transparent tracking system. This tracking system should be able to deliver results in real time. In addition, the tracking system should enable the sponsor to pinpoint each affiliate's role in the sale in order to disburse the sales incentives to affiliates in a fair and transparent manner.

Watch out for link hijacking. Link hijacking is a very common problem faced by affiliate marketers. Some affiliates may cut off the ID from the affiliate link thereby robbing the affiliate of the much deserved commission from the sale. There are software in the market that you can use to overcome this. These software work by hiding affiliate ID from visible links thus ensuring that the affiliate gets due credit from his leads.

Alongside these tips you can also avoid affiliate scams by doing the following:

Joining forums that expose affiliate frauds. Having your own blacklist for reference. Regular communication with affiliate sponsors. Ensuring that the affiliates actually have a website with relevant content. Installing site lock feature on your website to prevent data theft. Looking for reviews of the products you want to buy,you can see an example of a honest review here:Is Bring the Fresh Scam or Legit. While pondering how to avoid affiliate scams online, it is important that you are aware of different types of frauds and their modus operandi. Understanding how these programs operate will provide you with insights into how you can avoid affiliate marketing frauds and make money online from the comfort of your home.

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